Fig. 1: Effect of FOXO3 Genotype on Telomere Length During Aging in Men and Women.
From: Novel protective effect of the FOXO3 longevity genotype on mechanisms of cellular aging in Okinawans
The populations were divided into young (ages 19–54 years) and old (ages ≥55 years) for men (a, b) and women (c, d), respectively. For young participants, FOXO3 genotype did not significantly affect telomere length as a function of age (P > 0.1 for men and women). In contrast, FOXO3 genotype had a significant protective effect on telomere length in old male and female participants (P < 0.001). Telomere length was assessed using monochrome multiplex quantitative polymerase chain reaction (mmqPCR)49. Telomere length was determined as a telomere/single copy gene (T/S) ratio as a reference to Ct value of each respective gene expression reaction.
