Fig. 3: Effect of FOXO3 Genotype on FOXO3 Expression During Aging.
From: Novel protective effect of the FOXO3 longevity genotype on mechanisms of cellular aging in Okinawans
FOXO3 expression was analyzed for young (a, age 19–54 years) and old (b, age ≥ 55 years) participants using real time PCR. Possession of the longevity FOXO3 G-allele was associated with better retention of FOXO3 gene expression as a function of age in young (a; n = 100, TT = 61, G-allele carriers = 39; P = 0.02), and with a trend toward significance in the old (b; n = 124, TT = 69, G-allele carriers = 55; P = 0.08) participants.
