Fig. 4: Effect of FOXO3 Genotype on IL-6 Levels in Women and Men ≥ 55 years.
From: Novel protective effect of the FOXO3 longevity genotype on mechanisms of cellular aging in Okinawans
Relative IL-6 levels were assessed as a function of genotype in the older female population (a) (n = 80, TT = 43, G-allele carriers = 37). Possession of the G-allele was associated with protection against increasing levels of the pro-inflammatory cytokine IL-6 as a function of age that approached significance when compared to individuals with the TT genotype (P = 0.07). Relative IL-6 levels were assessed as a function of genotype in the older male population (b) (n = 78, TT = 42, G-carriers = 36). Possession of the G-allele did not confer any benefit as a function of age when compared to the TT genotype (P > 0.05). A significant sex-specific effect was observed, namely, females demonstrated robust protection against increasing levels of IL-6 as a function of age as compared to males (P = 0.0006). No effect of FOXO3 genotype on IL6 levels was observed in the young.
