Table 1 Summary of MRI measures used to derive brain health phenotypes

Brain structure^a		Functional connectivity^b
banks superior temporal	para hippocampal	Graph Theory Metrics	Brain Network
caudal anterior cingulate	pars opercularis	Global Efficiency Local Efficiency Small World Propensity Strength	default mode
caudal middle frontal	pars orbitalis		dorsal attention
Cuneus	pars triangularis		frontoparietal
Entorhinal	pericalcarine		limbic
frontal pole	postcentral		motor
Fusiform	posterior cingulate		ventral attention
inferior parietal	precentral		visual
inferior temporal	precuneus		whole brain
Insula	rostral anterior cingulate
isthmus cingulate	rostral middle frontal	Brain metabolism^c
lateral occipital	superior frontal	Metabolite	Region
lateral orbitofrontal	superior parietal	Choline	Anterior and Posterior Cingulate Cortex
Lingual	superior temporal	Creatine
medial orbitofrontal	supramarginal	NAA
middle temporal	temporal pole
para central	transverse temporal

^aThe structural regions were measured for both volumetrics (right and left hemispheres measured separately) and white matter.
^bFunctional connectivity included eight brain networks measured by four separate graph theory metrics.
^cThe concentrations of the three brain metabolites were measured in the same region of the brain. NAA is N-acetyl aspartate.

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