Fig. 1: Cohort characteristics.

A CONSORT diagram; B Breakdown of samples between the analyses. Black rectangles indicate that the analysis was performed. Tissue sources for the analyses were as follows: Metabolomics – blood plasma and myocardial biopsies, Mitochondrial respiration – blood mononuclear cells, Transcriptomics, targeted metabolomics, rDNA, DNA damage, Nucleolin and Fibrillarin – myocardial biopsies, SASP – blood plasma. C Comorbidities distribution in participants without or with a specific number of comorbidities; D Comorbidities distribution in participants without and with multimorbidity. Colors in C and D indicate the system affected by a comorbidity.