Fig. 2: Metabolite analysis. | npj Aging

Fig. 2: Metabolite analysis.

From: Multimorbidity is associated with myocardial DNA damage, nucleolar stress, dysregulated energy metabolism, and senescence in cardiovascular disease

Fig. 2: Metabolite analysis.

A Principal component (1 and 2) plots for the detected metabolites in the myocardial biopsies and plasma. B KEGG metabolite set enrichment analysis in plasma samples with enriched metabolites. The color scales indicate metabolite log fold change (with positive number indicating upregulation in multimorbidity) or pathway enrichment p-value. C KEGG metabolite set enrichment analysis in plasma in complex multimorbidity and in reduced datasets to test the influence of each comorbidity and anti-diabetic medications. Black squares indicate significantly enriched pathways for specific dataset. Numbers in square brackets indicate the number of non-multimorbid/multimorbid patients.

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