Fig. 3: Myocardial transcripts analysis.

A Principal component (1 and 2) plots for the myocardial transcriptomics profiles. B Network eigengene values distribution between the groups. Genes constituting each network were subjected to pathway enrichment analysis, and the summary is shown below the plots. Font colors indicate pathways enriched by genes in each of four networks. The full list of pathways is in Table S6. The numbers in each plot show a correlation estimate (p-value) between network eigengene values and the number of comorbidities. C Outcome of gene set enrichment analysis. The bar plot shows significantly regulated pathways (adjusted p-value < 0.05) specifically in multimorbidity but not the comorbidities The full list is in Table S7. The diagrams show transcripts sharing membership in at least one pathway. The node fill color shows transcripts’ log fold change with positive numbers indicating upregulation in multimorbidity. The colors in the node border indicate a number of pathways the transcript participates in. Box colors in the diagram and corresponding colors of pathway names indicate pathways sharing genes.