Table 1 Representative studies considering IFP-stem cells for cartilage regeneration

From: Knee adipose tissue: from its implication in osteoarthritis to its supposed role in tissue engineering

Cell source

Support/scaffold

Outcome

Reference

Pig IFP-MSCs

Agarose hydrogel

Chondrogenesis with GAGs and collagen accumulation in culture

61

Pig IFP-MSCs

Self-assembled

Formation of a dense cartilage tissue with cartilage ECM accumulation

62

Human IFP- MSCs

Pellet coculture of OA chondrocytes and IPFP-derived MSCs with chitosan/hyaluronic acid nanoparticles

Promoting chondrogenic differentiation and preventing articular chondrocytes inflammation and the hypertrophic differentiation of MSCs

63

Sheep IFP- MSCs

Nanofiber polycaprolactone scaffold

Chondrogenic differentiation

64

Rabbit IFP-MSCs

Decellularizated bone cartilage composite scaffolds

The decellularized ECM loaded with IFP-MSCs promotes rabbit osteochondral defects repair

65

Human IFP-MSCs

—

Pain reduction and improved function in patients with knee cartilage lesions

66

Rabbit IFP-MSCs

Pure PRP

Good repair effect in animal cartilage defect model (rabbit)

67

Human IFP-MSCs

—

Improvement of disease symptoms

68

  1. ECM, extracellular matrix; GAGs, glycosaminoglycans; IFP-MSCs, infrapatellar fat pad- mesenchymal stem cells; PRP, platelet rich plasma.
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