Fig. 2: Salidroside rebuilds ovarian vasculature to enhance fertility in aged females.

In illustrations resembling a traditional Chinese three-frame screen, the left frame depicted a healthy and active blood supply (depicted as a river) facilitating the transportation of nutrients and hormones (represented by colorful fishes) to support the high-quality development of ovarian follicles (depicted as a Ruan, a Chinese traditional instrument, in the lady’s hand). These well-developed follicles secrete adequate sexual hormones (depicted as flowers) to sustain active fertility. In middle-aged females, the aging of ovarian blood vessels (depicted as a frozen river) results in a reduction of upstream hormones reaching the ovaries, causing a blockage in follicle development and ultimately resulting in a decline in female reproduction (illustrated in the middle frame). However, the administration of Salidroside (depicted as red grass on the mountains) has been proven effective in restoring ovarian angiogenesis, enhancing blood supply to middle-aged ovaries, thereby promoting follicle development and restoring fertility in aging females (illustrated in the right frame). (Designed by Hua Zhang, illustrated by Ruobing Yang.).