Fig. 6: The effects of PCC1 on SnCs. | npj Aging

Fig. 6: The effects of PCC1 on SnCs.

From: Single-cell profiling unveils a geroprotective role of Procyanidin C1 in hematopoietic immune system via senolytic and senomorphic effects

Fig. 6

A Violin plot showing the SenCID score across six SID types. B Violin plot showing the normalized SID6 score across the indicated groups. C Bar plot showing the relative ratio of SnCs identified by SenCID across the indicated groups. D Violin plot showing the SenMayo score across the indicated groups. E Venn diagram showing the intersection of SnCs identified by SenClD and SenMayo analysis. The overlapping SnCs were referred to as inferred SnC (iSnC). F Bar plot showing the relative ratio of SnC across the indicated cell types. Bar plot showing the pathway analysis of upregulated (G) and downregulated (H) DEGs in SnC/NonSnC comparison. FCM histograms (left) and column charts (right) showing the MFI of β-Gal in BM (I) and SP (J) CD45+ cells across the indicated groups (n = 5/group). FCM histograms (left) and column charts (right) showing the MFI of β-Gal in subpopulations of BM (K) and SP (L) across the indicated groups (n = 5/group). Significance was calculated using one-way ANOVA test (D, I, J) or two-way ANOVA test (K, L); ns, not significant, *P < 0.01, **P < 0.01, ***P < 0.001, ****P < 0.0001.

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