Table 2 Top 10 experiments in Mus musculus ranked by significant average/median lifespan extension in females
From: Sex-specific insights into drug-induced lifespan extension and weight loss in mice
Compound | Strain | Dosage | Age at initiation | Avg/med lifespan change | Max lifespan change | Weight change | ITP | PMID | Year |
|---|---|---|---|---|---|---|---|---|---|
Metformin | SHR | 100 ppm water | 3 months | 38% | 21% | NS | No | 18728386 | 2008 |
Pineal gland extract | C3H/Sn | 0.5 mg subcutaneous injection 5 days monthly | 3.5 months | 31% | 14% | NA | No | 6752596 | 1982 |
Thymus extract | C3H/Sn | 0.5 mg subcutaneous injection 5 days monthly | 3.5 months | 28% | 11% | NA | No | 6752596 | 1982 |
2-mercaptoethylamine hydrochloride | C3H | 10,000 ppm food | after weaning | 26% | NA | −1% | No | 13711616 | 1961 |
Rapamycin | UM-HET3 | 42 ppm food | 9 months | 26% | 11% | −20% | Yes | 24341993 | 2014 |
X203 (anti-IL-11) | C57BL/6 J | 40 ppm bodyweight monthly intraperitoneal injection | 17.2 months | 25% | NA | NA | No | 39020175 | 2024 |
Butylated hydroxytoluene | BaLB/c | 7500 ppm food | 2.6 months | 25% | NS | NA | No | 448040 | 1979 |
Rapamycin | UM-HET3 | 14 ppm food | 9 months | 21% | 11% | −4% | Yes | 24341993 | 2014 |
Phenformin | C3H/Sn | 2 mg oral gavage 5 times a week | 3.5 months | 21% | 28% | NA | No | 14618027 | 2003 |
Calcium pantothenate | C57BL/6 | 300 µg/day in water | 1 month | 20% | NA | 12% | No | 13614445 | 1958 |
