Table 2 Metabolites that changed in the longitudinal analysis from serum collected at baseline, 9 weeks and after washout in vehicle, GinA (10 mg/kg) and modGinA (27 mg/kg)

From: Senolytic effects of a modified Gingerenone A

Class

Metabolites

Amino Acids, amino acid related and Biogenic Amines

alpha-AAA,Anserine,beta-Ala,Choline,GABA, Thr

Cholesterol Esters (10)

CE 14:0,CE 15:0,CE 16:0,CE 16:1,CE 18:1,CE 18:2,CE 18:3,CE 20:3,CE 20:4,CE 20:5

Ceramides (5)

Cer d18:1/24:0,Cer d18:1/24:1,Cer d18:2/24:0, Hex-Cer d18:1/20:0,Hex-Cer d18:1/24:1

Sphingomyelins (7)

SM 34:1,SM 35:1,SM 36:1,SM 36:2,SM 42:1,SM 42:2,SM 43:1

Carboxylic acids

Lactic Acid

Cresol

p-Cresol-SO4

Lysolipids (2)

LPE 18:0,LPE P-18:1

Glycerides (3)

MG 18:1,MG 20:3, TG 18:2_36:0

Phosphatidic Acids (11)

PA 16:2_18:1,PA 17:1_18:1,PA 17:2_18:1,PA 18:0_18:1,PA 18:1_18:1,PA 18:1_18:3,PA 18:1_18:4,PA 18:1_20:3,PA 18:1_22:3,PA 18:2_18:2,PA 18:2_22:3

Phosphatidylcholines (2)

PC O-34:0,PC O-36:0

Phoshpatidylethanolamines (11)

PE 33:1,PE P-16:0/15:0,PE P-16:0/16:0,PE P-16:0/18:1,PE P-16:0/20:5,PE P-18:0/18:1,PE P-18:0/20:5,PE P-18:1/18:1,PE P-18:1/18:2,PE P-18:1/20:4,PE P-20:0/20:5

Phosphatidylglycerols (10)

PG 16:0_16:0,PG 16:0_18:1,PG 16:0_20:3,PG 16:2_18:1,PG 17:0_18:1,PG 17:1_18:1,PG 18:1_18:1,PG 18:1_20:0,PG 18:1_20:1,PG 18:2_20:0

Phosphatidylinositols (4)

PI 16:0_16:0,PI 18:1_20:1,PI 18:1_20:2,PI 18:1_22:0

Phosphatidylserine

PS 36:1