Table 1 Number of identified senescent neurons in the discovery dataset (Mathys 2019), and the three external validation datasets: Zhou 2020, Xiong 2023, and Mathys 2024

Number of brain samples

48

32

92

48

Number of samples with AD pathology

24

19

44

26

Median ± sd of age

89.5 ± 4.4

89.3 ± 6.2

87.5 ± 3.8

87.5 ± 5

Total number of cells (PFC)

80,000

70,000

400,000

255,000

Senescent neurons (CSP+, SIP+, & SenMayo+)

475

255

124

1178

Non-Senescent neurons (CSP^-, SIP^-, & SenMayo^-)

16,871

4003

95,144

37,061

Total excitatory neurons

34,976

12,590

173,246

112,143

Total inhibitory neurons

9196

3727

61,056

40,290