Fig. 3: Dietary oleic acid supports recovery of microbiome from antibiosis.
a Bacterial taxonomic summary of young and old animals receiving dietary intervention with normal (ND), palmitic acid (PA) enriched diet (ED) or oleic acid (OA) ED before (B), 4 days (At1) and 7 weeks (At2) after antibiosis. b Relative abundance (%) of bacteria at phylum level dependent on age and nutrition before (B) and after (At1) antibiosis. c Principal coordinates analysis of beta-diversity based on Bray-Curtis distances shows microbiome diversity in animal samples before (B) and after (At1) antibiosis, grouped by age and nutrition. d Network analyses of microbial composition in different nutrition (ND, PA-ED, OA-ED) and age (young vs old) groups before (B) and after (At1) antibiosis (AB). Besides networks, computed values for modularity (M), nodes and edges are depicted. Data derived from 3 to 7 mice per condition. DI dietary intervention, ND normal diet, PA-ED palmitic acid enriched diet, OA-ED oleic acid enriched diet, AB antibiosis. Statistical analysis in (c): Permanova statistical test; **p ≤ 0.01.
