Fig. 4: Palmitic acid destabilizes microbiome of old animals making it more susceptible to P. gingivalis- induced changes. | npj Aging

Fig. 4: Palmitic acid destabilizes microbiome of old animals making it more susceptible to P. gingivalis- induced changes.

From: Mediterranean diet component oleic acid decreases systemic impact of periodontal Porphyromonas gingivalis-infection in age: addressing role of stress resistance and microbiome

Fig. 4: Palmitic acid destabilizes microbiome of old animals making it more susceptible to P. gingivalis- induced changes.

a Relative taxonomic distribution pattern in young and old animals fed either with ND, PA-ED or OA-ED and infected with Porphyromonas gingivalis (P.g.) in comparison to PBS-infected CTRL animals. b Modularity measured at different time points (after 1 week of DI (1wk), after 8 weeks of DI/before antibiosis (8wk/At1), after antibiosis, after infection (uninfected also At2), young–left, old—right). c Sum of Bray-Curtis distances across different treatment phases, including time points (1 wk - 8 wk), antibiotic treatment (beforeAB—afterAB), and infection (afterAB vs. infection with Pg). d Cumulative Bray-Curtis distance reflects the overall microbiome changes throughout the various treatment phases. (time, antibiosis, infection) (young—left, old—right). Data derived from 3 to 7 mice per condition. DI dietary intervention, ND normal diet, PA-ED palmitic acid enriched diet, OA-ED oleic acid enriched diet, CTRL control, P.g. – Porphyromonas gingivalis.

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