Table 2 Associations of YSM one unit, metabolomic signature per SD increment with aging biomarkers in UK Biobank baseline data

From: Years since menopause and its metabolomic signature with biological aging in women at midlife: a population-based study

 

YSM*

Metabolic signature

 

OR (95%CI)

P

OR (95%CI)

P

Long TL

 Model 1

0.90 (0.88, 0.92)

<0.001

0.92 (0.90, 0.93)

<0.001

 Model 2

0.91 (0.89, 0.93)

<0.001

0.92 (0.90, 0.94)

<0.001

 Model 3

0.92 (0.90, 0.93)

<0.001

0.93 (0.91, 0.95)

<0.001

 Model 4

0.92 (0.90, 0.94)

<0.001

0.94 (0.92, 0.96)

<0.001

High AL

 Model 1

1.13 (1.11, 1.15)

<0.001

1.66 (1.63, 1.70)

<0.001

 Model 2

1.11 (1.09, 1.13)

<0.001

1.65 (1.61, 1.68)

<0.001

 Model 3

1.11 (1.09, 1.14)

<0.001

1.54 (1.50, 1.57)

<0.001

 Model 4

1.07 (1.05, 1.10)

<0.001

1.53 (1.49, 1.56)

<0.001

High PA

 Model 1

1.14 (1.07, 1.20)

<0.001

2.54 (2.40, 2.69)

<0.001

 Model 2

1.10 (1.04, 1.17)

0.001

2.48 (2.34, 2.63)

<0.001

 Model 3

1.09 (1.03, 1.15)

0.005

2.30 (2.17, 2.44)

<0.001

 Model 4

1.02 (0.96, 1.08)

0.617

2.30 (2.17, 2.44)

<0.001

  1. CI Confidence Interval, OR Odds Ratio, TL Telomere Length, AL Allostatic Load, PA PhenoAge.
  2. *One unit representing a 5-year interval.
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