Table 1 EP300mut LCLs used for in vitro treatments

From: p300 inhibition delays premature cellular senescence

Gene

EP300mut LCLs

cDNA change

Protein change

Mutation type

Reference

EP300

RSTS 25

c.41_51delinsT

p.(K14Ifs*31)

Frameshift

Negri et al. 52

RSTS 39

c.4640dupA

p.(N1547Kfs*3)

Frameshift

Negri et al. 53

RSTS 54

c.669dupT

p.(Q223Sfs*19)

Frameshift

Negri et al. 52

RT010-15

c.4763T > C

p.(M1588T)

Missense (HAT)

Di Fede et al. 54

  1. HAT histone acetyltransferase domain.
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