Fig. 1: Scheme showing the phenomenon of ovarian aging and its effects on the decrease of the antral follicle count (AFC), and of the anti-Muellerian Hormone (AMH) in the bloodstream of women with advancing age.
From: Sirtuins and their role in ovarian aging-related fibrosis predisposing to ovarian cancer

With increasing age, symptoms of fibrosis increase, and by this, the risk for tumorigenesis is elevated, too.