Fig. 3: Relationship between age and intensity signal of chromosome Y in the Biobank Japan dataset. | npj Aging

Fig. 3: Relationship between age and intensity signal of chromosome Y in the Biobank Japan dataset.

From: Local radiotherapy for cancer patients is associated with mosaic loss of chromosome Y, a hallmark of male aging

Fig. 3: Relationship between age and intensity signal of chromosome Y in the Biobank Japan dataset.

Scatter plots for the first cohort, illustrating the relationship between age and chr Y intensity in prostate cancer (A), lung cancer (B), colorectal cancer (C), and gastric cancer (D). Scatter plots for the second cohort, depicting the same relationships in prostate cancer (E), lung cancer (F), colorectal cancer (G), and gastric cancer (H). The dashed line represents the threshold for the mLOY signals, defined as the top 1% of individuals with the lowest mLRR-Y. Gray and blue dots indicate patients who did not receive radiotherapy (non-RT) and those who did (RT), respectively. Regression lines for non-RT (gray) and RT (blue) groups are shown, with corresponding equations and P-values.

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