Table 2 Characteristics of prostate, lung, colorectal, and gastric cancer patients in Biobank Japan

From: Local radiotherapy for cancer patients is associated with mosaic loss of chromosome Y, a hallmark of male aging

Characteristic

Prostate

Lung

Colorectal

Gastric

First cohort

Subjects, N

5090

2637

4303

4793

Age (mean ± SD)

72.8 ± 6.9

67.8 ± 9.3

67.7 ± 9.0

67.2 ± 9.7

Local radiotherapy, N (%)

925 (18.2)

426 (16.2)

98 (2.3)

69 (1.4)

mLOY, N (%)

109 (2.14)

32 (1.21)

55 (1.28)

52 (1.08)

mLOY in RT, N (%)

23 (21.1)

7 (21.9)

1 (1.82)

1 (1.92)

Second cohort

Subjects, N

5582

1800

3910

2731

Age (mean ± SD)

72.4 ± 7.5

69.7 ± 9.8

68.2 ± 10.4

70.5 ± 9.1

Local radiotherapy, N (%)

1848 (33.1)

451 (25.1)

325 (8.3)

99 (3.6)

mLOY, N (%)

69 (1.24)

20 (1.11)

41 (1.05)

35 (1.28)

mLOY in RT, N (%)

24 (34.8)

7 (35.0)

4 (9.76)

2 (5.71)

  1. mLOY mosaic loss of chromosome Y, RT radiotherapy, SD standard deviation.