Table 2 Associations of BA acceleration with all-cause mortality and cardiovascular mortality

From: Biological aging, left ventricular dysfunction and mortality in patients with heart failure with preserved ejection fraction

  

Model 1

Model 2

Model 3

 

Event/total (%)

HR (95% CI)

P value

HR (95%CI)

P value

HR (95%CI)

P value

KDMAge acceleration

All-cause mortality

 per SD increase

321/1727 (18.6)

1.62 (1.47, 1.78)

<0.001

1.59 (1.44, 1.75)

<0.001

1.55 (1.40, 1.72)

<0.001

 Tertile1

80/575 (13.9)

Reference

–

Reference

–

Reference

–

 Tertile2

85/575 (14.8)

1.13 (0.83, 1.55)

0.409

1.22 (0.89, 1.67)

0.206

1.18 (0.86, 1.62)

0.287

 Tertile3

156/577 (27.0)

2.41 (1.83, 3.19)

<0.001

2.40 (1.81, 3.18)

<0.001

2.31 (1.73, 3.09)

<0.001

 P for trend

 

<0.001

 

< 0.001

 

< 0.001

 

Cardiovascular mortality

 per SD increase

180/1727 (10.4)

1.54 (1.34, 1.77)

<0.001

1.51 (1.32, 1.73)

<0.001

1.47 (1.28, 1.69)

<0.001

 Tertile1

48/575 (8.3)

Reference

–

Reference

–

Reference

–

 Tertile2

45/575 (7.8)

1.03 (0.67, 1.57)

0.879

1.12 (0.73, 1.72)

0.579

1.08 (0.70, 1.66)

0.706

 Tertile3

87/577 (15.1)

2.21 (1.52, 3.21)

<0.001

2.16 (1.48, 3.16)

<0.001

2.06 (1.39, 3.05)

<0.001

P for trend

 

<0.001

 

<0.001

 

<0.001

 

PhenoAge acceleration

All-cause mortality

 per SD increase

321/1727 (18.6)

1.27 (1.13, 1.42)

<0.001

1.26 (1.12, 1.41)

<0.001

1.24 (1.11, 1.40)

<0.001

 Tertile1

85/575 (14.8)

Reference

–

Reference

–

Reference

–

 Tertile2

100/575 (17.4)

1.20 (0.89, 1.61)

0.229

1.23 (0.91, 1.66)

0.160

1.24 (0.92, 1.68)

0.145

 Tertile3

136/577 (23.6)

1.62 (1.22, 2.17)

<0.001

1.66 (1.24, 2.22)

<0.001

1.66 (1.24, 2.22)

<0.001

 P for trend

 

<0.001

 

<0.001

 

<0.001

 

Cardiovascular mortality

 per SD increase

180/1727 (10.4)

1.24 (1.06, 1.45)

0.006

1.23 (1.05, 1.44)

0.010

1.21 (1.04, 1.41)

0.015

 Tertile1

52/575 (9.0)

Reference

–

Reference

–

Reference

–

 Tertile2

46/575 (8.0)

0.96 (0.64, 1.46)

0.880

0.99 (0.65, 1.50)

0.985

0.93 (0.61, 1.40)

0.738

 Tertile3

82/577 (14.2)

1.62 (1.11, 2.38)

0.012

1.66 (1.12, 2.44)

0.009

1.64 (1.12, 2.39)

0.009

 P for trend

 

0.005

 

0.004

 

0.005

 
  1. BA biological age, HR hazard ratio, CI confidence interval, Model 1 adjusted by sex, age, Model 2 adjusted by model 1 + drinking, smoking, history of hypertension, coronary artery disease, diabetes, atrial fibrillation, and stroke, Model 3 adjusted by model 2 + lipid lowering medications, antihypertension medications, oral hypoglycemic agent,s and insulin use.
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