Table 3 Associations of BA acceleration with left ventricular structure and function
Model 1 | Model 2 | Model 3 | ||||
|---|---|---|---|---|---|---|
β (95% CI) | P value | β (95% CI) | P value | β (95% CI) | P value | |
LV structure | ||||||
LVMI, g/m2 | ||||||
KDMAge acceleration | 9.51 (6.98, 12.05) | <0.001 | 9.36 (6.81, 11.91) | <0.001 | 8.87 (6.25, 11.50) | <0.001 |
PhenoAge acceleration | 4.28 (1.64, 6.93) | 0.001 | 4.11 (1.45, 6.77) | 0.002 | 3.34 (0.62, 6.07) | 0.015 |
RWT | ||||||
KDMAge acceleration | 0.006 (0.002, 0.01) | 0.005 | 0.006 (0.002, 0.01) | 0.005 | 0.006 (0.001, 0.01) | 0.010 |
PhenoAge acceleration | 0.005 (0.001, 0.009) | 0.020 | 0.005 (0.001, 0.009) | 0.022 | 0.004 (0.0002, 0.009) | 0.038 |
LV systolic function | ||||||
LVEF, % | ||||||
KDMAge acceleration | −0.303 (−0.663, 0.056) | 0.098 | −0.310 (−0.668, 0.047) | 0.089 | −0.176 (−0.545, 0.191) | 0.347 |
PhenoAge acceleration | −0.272 (−0.642, 0.097) | 0.148 | −0.285 (−0.654, 0.083) | 0.129 | −0.144 (−0.521, 0.232) | 0.452 |
LV diastolic function | ||||||
E/A | ||||||
KDMAge acceleration | 0.008 (−0.017, 0.034) | 0.526 | 0.013 (−0.011, 0.038) | 0.302 | −0.003 (−0.028, 0.023) | 0.837 |
PhenoAge acceleration | 0.013 (−0.014, 0.041) | 0.340 | 0.018 (−0.008, 0.045) | 0.174 | 0.003 (−0.024, 0.030) | 0.835 |
E/e’ ratio, % | ||||||
KDMAge acceleration | 0.889 (0.638, 1.141) | <0.001 | 0.887 (0.637, 1.138) | <0.001 | 0.641 (0.388, 0.894) | <0.001 |
PhenoAge acceleration | 0.613 (0.344, 0.881) | <0.001 | 0.601 (0.333, 0.869) | <0.001 | 0.341 (0.073, 0.609) | 0.012 |
