Table 1 Baseline characteristics of the 39 participants included in the study
From: MicroRNA profiles in plasma-derived extracellular vesicles across the human lifespan
Total (n = 39) | Male (n = 21) | Female (n = 19) | p | |
|---|---|---|---|---|
Age (years) | 48.5 (20–85) ± 2.8 | 49.3 (23–79) ± 3.9 | 47.6 (20–85) ± 4.3 | 0.767 |
Sex (female) | 19 (49%) | − | − | |
Height (m) | 1.69 (1.47–1.87) ± 0.01 | 1.77 (1.61–1.87) ± 0.01 | 1.61 (1.47–1.69) ± 0.01 | <0.001* |
Weight (kg) | 69.7 (44.5–100) ± 2.27 | 78.2 (58.8–100) ± 2.6 | 58.6 (44.5–77.2) ± 2.0 | <0.001* |
Body mass index (kg/m2) | 23.8 (17.3–35.7) ± 0.6 | 25.1 (19.4–30.8) ± 0.7 | 22.5 (17.3–35.7) ± 0.9 | 0.025* |
Basal metabolic rate | 1517 (1095–2130) ± 45.8 | 1738 (1297–2130) ± 47.1 | 1284 (1095–1500) ± 27 | <0.001* |
Body fat mass (kg) | 16.0 (5.8–39.1) ± 1.1 | 15.6 (5.8–31.5) ± 1.4 | 16.3 (7.4–39.1) ± 1.8 | 0.776 |
Soft lean mass (kg) | 49.6 (31.4–77.1) ± 2.0 | 58.9 (40.5–77.1) ± 2.0 | 39.8 (31.4–49.3) ± 1.2 | <0.001* |
Fat-free mass | 52.7 (33.6–81.5) ± 10.6 | 62.5 (42.9–81.5) ± 2.1 | 42.3 (33.6–52.3) ± 1.3 | <0.001* |
Visceral fat area | 75.1 (22.2–202.8) ± 6.4 | 72.7 (22.2–156.8) ± 7.7 | 77.6 (27.7–202.8) ± 10.6 | 0.708 |
Waist-hip ratio | 0.900 (0.900–1.09) ± 0.010 | 0.910 (0.790–1.08) ± 0.020 | 0.880 (0.790–1.09) ± 0.020 | 0.393 |
50 kHz body phase angle | 5.53 (3.60–6.70) ± 0.13 | 5.90 (3.60–6.70) ± 0.17 | 5.16 (3.90–6.20) ± 0.15 | 0.004* |
Physical performance | ||||
Grip Strength (kg/cm) | 30.6 (10.5–53.4) ± 1.8 | 39.4 (27.5–53.4) ± 1.5 | 21.4 (10.5–35.9) ± 1.5 | <0.001* |
Chair Test (s) | 9.40 (5.30–20.7) ± 0.50 | 9.40 (6.40–20.7) ± 0.70 | 9.40 (5.30–15.93) ± 0.60 | 0.949 |
Walking speed (normal) (s) | 3.50 (2.23–4.43) ± 0.07 | 3.50 (2.76–4.43) ± 0.10 | 3.50 (2.23–4.06) ± 0.10 | 0.748 |
Walking speed (fast) (s) | 2.23 (0.72–3.28) ± 0.07 | 2.10 (0.72–3.00) ± 0.09 | 2.40 (1.80–3.28) ± 0.09 | 0.016* |
Inflammatory markers | ||||
GDF-15 | 446 (131–1335) ± 40 | 465 (131–1335) ± 63 | 428 (219–1011) ± 50 | 0.646 |
Exosomes characterization | ||||
Extracellular vesicles number (particles/mL) | 4.99 × 108 (1.34 × 107–5.95 × 109) ± 1.75 × 108 | 6.29 × 108 (1.34 × 107–5.95 × 109) ± 2.94 × 108 | 3.61 × 108 (2.21 × 107–3.70 × 109) ± 1.87 × 108 | 0.452 |
Extracellular vesicles size (nm) | 139 (110–175) ± 3 | 136 (110–162) ± 3 | 143 (112–175) ± 4.0 | 0.134 |
