Table 1 Baseline characteristics by modifiable risk factor score and polygenic risk score categories
Characteristics | Modifiable risk factor score | P value | Polygenic risk score | P value | |||
|---|---|---|---|---|---|---|---|
High | Medium | Low | Low | High | |||
N | 515 | 514 | 516 | 782 | 763 | ||
Age (mean (SD)) | 99.05 (7.65) | 94.93 (9.54) | 92.52 (9.47) | <0.001 | 94.16 (9.54) | 96.87 (8.89) | <0.001 |
Age group | |||||||
80-99 years | 119 (23.1) | 226 (44.0) | 295 (57.2) | <0.001 | 385 (49.2) | 255 (33.4) | <0.001 |
≥100 years | 396 (76.9) | 288 (56.0) | 221 (42.8) | 397 (50.8) | 508 (66.6) | ||
Sex | |||||||
Male | 93 (18.1) | 117 (22.8) | 210 (40.7) | <0.001 | 199 (25.4) | 221 (29.0) | 0.135 |
Female | 422 (81.9) | 397 (77.2) | 306 (59.3) | 583 (74.6) | 542 (71.0) | ||
Marital status | |||||||
Married | 99 (19.2) | 145 (28.2) | 174 (33.7) | <0.001 | 231 (29.5) | 187 (24.5) | 0.03 |
Others | 416 (80.8) | 369 (71.8) | 342 (66.3) | 551 (70.5) | 576 (75.5) | ||
Work | |||||||
Manual | 512 (99.4) | 498 (96.9) | 482 (93.4) | <0.001 | 754 (96.4) | 738 (96.7) | 0.851 |
Non-manual | 3 (0.6) | 16 (3.1) | 34 (6.6) | 28 (3.6) | 25 (3.3) | ||
Disease | |||||||
CVD | 29 (5.6) | 32 (6.2) | 91 (5.9) | 0.927 | 49 (6.3) | 42 (5.5) | 0.598 |
Stroke | 13 (2.5) | 11 (2.1) | 38 (2.5) | 0.825 | 21 (2.7) | 17 (2.2) | 0.677 |
Cancer | 1 (0.2) | 4 (0.8) | 7 (0.5) | 0.369 | 3 (0.4) | 4 (0.5) | 0.974 |
Education | |||||||
Healthy | 6 (1.2) | 21 (4.1) | 73 (14.1) | <0.001 | 50 (6.4) | 50 (6.6) | 0.981 |
Unhealthy | 509 (98.8) | 493 (95.9) | 443 (85.9) | 732 (93.6) | 713 (93.4) | ||
Depression | |||||||
Healthy | 251 (48.7) | 402 (78.2) | 473 (91.7) | <0.001 | 579 (74.0) | 547 (71.7) | 0.326 |
Unhealthy | 264 (51.3) | 112 (21.8) | 43 (8.3) | 203 (26.0) | 216 (28.3) | ||
Smoking | |||||||
Healthy | 421 (81.7) | 453 (88.1) | 452 (87.6) | 0.005 | 682 (87.2) | 644 (84.4) | 0.131 |
Unhealthy | 94 (18.3) | 61 (11.9) | 64 (12.4) | 100 (12.8) | 119 (15.6) | ||
Alcohol | |||||||
Healthy | 439 (85.2) | 421 (81.9) | 358 (69.4) | <0.001 | 638 (81.6) | 580 (76.0) | 0.009 |
Unhealthy | 76 (14.8) | 93 (18.1) | 158 (30.6) | 144 (18.4) | 183 (24.0) | ||
Physical activity | |||||||
Healthy | 37 (7.2) | 173 (33.7) | 458 (88.8) | <0.001 | 352 (45.0) | 316 (41.4) | 0.169 |
Unhealthy | 478 (92.8) | 341 (66.3) | 58 (11.2) | 430 (55.0) | 447 (58.6) | ||
Diet | |||||||
Healthy | 202 (39.2) | 242 (47.1) | 203 (39.3) | 0.014 | 353 (45.1) | 294 (38.5) | 0.01 |
Unhealthy | 313 (60.8) | 272 (52.9) | 313 (60.7) | 429 (54.9) | 469 (61.5) | ||
Sleep | |||||||
Healthy | 226 (43.9) | 310 (60.3) | 365 (70.7) | <0.001 | 462 (59.1) | 439 (57.5) | 0.573 |
Unhealthy | 289 (56.1) | 204 (39.7) | 151 (29.3) | 320 (40.9) | 324 (42.5) | ||
BMI | |||||||
Healthy | 93 (18.1) | 332 (64.6) | 425 (82.4) | <0.001 | 447 (57.2) | 403 (52.8) | 0.096 |
Unhealthy | 422 (81.9) | 182 (35.4) | 91 (17.6) | 335 (42.8) | 360 (47.2) | ||
Diabetes | |||||||
Healthy | 474 (92.0) | 459 (89.3) | 446 (86.4) | 0.015 | 702 (89.8) | 677 (88.7) | 0.563 |
Unhealthy | 41 (8.0) | 55 (10.7) | 70 (13.6) | 80 (10.2) | 86 (11.3) | ||
Hypertension | |||||||
Healthy | 121 (23.5) | 146 (28.4) | 171 (33.1) | 0.003 | 210 (26.9) | 228 (29.9) | 0.206 |
Unhealthy | 394 (76.5) | 368 (71.6) | 345 (66.9) | 572 (73.1) | 535 (70.1) | ||
Dyslipidemia | |||||||
Healthy | 393 (76.3) | 362 (70.4) | 353 (68.4) | 0.014 | 538 (68.8) | 570 (74.7) | 0.012 |
Unhealthy | 122 (23.7) | 152 (29.6) | 163 (31.6) | 244 (31.2) | 193 (25.3) | ||
Modifiable risk factor/ Polygenic risk score | |||||||
Low | 235 (45.6) | 282 (54.9) | 265 (51.4) | 0.011 | 265 (33.9) | 251 (32.9) | 0.011 |
Medium | 282 (36.1) | 232 (30.4) | |||||
High | 280 (54.4) | 232 (45.1) | 251 (48.6) | 235 (30.1) | 280 (36.7) | ||
