Fig. 5: Cross-resistance and collateral sensitivity to different antibiotics.

Heat map showing the changes in the resistance levels to six classes of antibiotics. Results shown are the log2 fold change in the minimum inhibitory concentrations (MIC) (mg/L) in the evolved CIP-resistant isolates compared to the sensitive ancestral strain. a The relative changes in the MIC levels in CIP-resistant isolates recovered from CIP-evolved populations. b The relative changes in the MIC levels in CIP-resistant isolates recovered from CTRL-evolved populations. CIP ciprofloxacin, CEF ceftazidime, MER meropenem, AZT aztreonam, TOB tobramycin, COL colistin.