Fig. 1: Gut microbiome landscape during pregnancy.

a Comparison of core genera (mean relative abundance >0.5%) between the pregnant women and the GGMP nonpregnant women. Twenty-five genera marked in red were dominant genera of both the pregnant women and GGMP nonpregnant women. b The enterotype analysis based on Jensen–Shannon divergence of the genus profile. The scatter plot shows that the pregnant women are split into three enterotypes, and the arrows indicate the top eight contributors to compositional variation. The bar chart shows the percentage of enterotype at each stage of pregnancy. c The overall landscape of all fecal samples from the pregnant women based on 489 core OTUs. Colored blocks of the circle nearest phylogenetic tree indicate genera and of the outermost circle indicate phyla. The heat map shows the mean relative abundance of each OTU in different stages of pregnancy. Blank asterisks indicate significantly at P ≤ 0.05 between the eight groups, and black asterisks indicate significantly at P ≤ 0.01 (one-way ANOVA test).