Fig. 1: Animal model and treatment regimen for drug repurposing evaluation.
From: Impact of the repurposed drug thonzonium bromide on host oral-gut microbiomes
a Thonzonium bromide (TB) chemical structure. b Cartoon illustration of TB-loaded into nanoparticle carrier. c Diagram of the animal experiment indicating the body site microbiome including oral (dental plaque and oral swab) and gut (feces). The treatment was performed twice a day for 3 weeks. Treatment groups included PBS, NPC, TB, and NPC.TB. d Table summarizing the characterization parameters of the NPC used in this study (NP13/3). PBS phosphate buffer saline, NPC nanoparticle carrier, TB thonzonium bromide, NPC.TB TB-loaded nanoparticle carrier, Mn number average molecular weight, PDI Polydispersity Index.
