Fig. 5: Oral-gut microbiome rodent model and microbiota disturbances by thonzonium bromide.
From: Impact of the repurposed drug thonzonium bromide on host oral-gut microbiomes
Gastrointestinal microbiome differs between oral-gut body sites. Our rodent model showed similar pattern of the microbial communities in oral (oral swab and dental plaque) and gut (feces) sites in human reported previously. This model was then applied to assess the impact of thonzonium bromide in the host microbiota; topical oral treatment caused localized microbiome disturbances while promoting turnover of specific oral species in the gut microbiota.
