Table 2 Impact of donor and supplementation of celecoxib (CX) or vehicle (PEG) on bacterial community metrics at (A) the beginning of the incubation (0 h, n = 6) and (B) once the incubation was finalized (16 h, n = 8).

From: Short-term supplementation of celecoxib-shifted butyrate production on a simulated model of the gut microbial ecosystem and ameliorated in vitro inflammation

Metric

Index

Treatment

SEM

P value of each effect

CX

PEG

Treatment

Donor

Treatment*Donor interaction

(A)

Evenness

Pielou

0.61

0.60

0.0009

0.83

0.0001

0.23

Alpha diversity

Shannon (H’)

2.71

2.72

0.03

0.81

<0.0001

0.13

Simpson

0.85

0.85

0.007

0.43

<0.0001

0.04

Inverse Simpson (D2)

8.00

8.48

0.53

0.54

<0.0001

0.76

Fisher’s diversity

13.41

13.16

0.25

0.49

<0.0001

0.34

Richness

Total richness (S)

92.50

95.83

3.83

0.55

0.002

0.77

Abundance

Chao

144.12

128.55

9.54

0.27

0.01

0.59

(B)

Evenness

Pielou

0.55

0.59

0.01

0.06

0.003

0.38

Alpha diversity

Shannon (H’)

2.54

2.70

0.06

0.08

0.001

0.33

Simpson

0.84

0.86

0.009

0.14

0.009

0.10

Inverse Simpson (D2)

7.59

8.13

0.63

0.55

0.02

0.23

Fisher’s diversity

13.28

13.17

0.25

0.49

<0.0001

0.34

Richness

Total richness (S)

92.56

97.12

2.78

0.88

0.005

0.07

Abundance

Chao

94.01

114.65

5.34

0.01

0.008

0.89