Fig. 6: Diagram of gut microbiome in the pathogenesis of CRC.
From: Metaproteomics characterizes human gut microbiome function in colorectal cancer
High iron concentration in the intestinal lumen of CRC patients promotes the production of reactive oxygen species (ROS) and results in high oxidative stress. Concentrations of superoxide dismutases (SODs) in the intestinal bacteria are increased. The excessive ROS cause DNA damage of intestinal epithelial cells and probiotic bacteria, which can accelerate the progression of CRC.
