Fig. 2: The microbiota composition of PepT1−/− mice is altered.
From: Impact of PepT1 deletion on microbiota composition and colitis requires multiple generations
a Principal component analysis (PCA) of the unweighted UniFrac distance matrix of fecal WT and PepT1−/− microbiota. b Microbiota richness and diversity in WT and PepT1−/− mice, based on the number of OTUs per sample. c Bacterial-taxon–based analysis of feces at the phylum level. d Firmicutes/Bacteroidetes ratio and relative abundance of Actinobacteria. Bacterial-taxon–based analysis of feces at the family level (e). Data are presented as the mean ± SEM. Unpaired two-tailed Student’s t-test (n = 10–16 mice/group; *P < 0.05). f LEfSe (LDA Effect Size) was used to investigate bacterial members that drive the differences in the fecal microbiota of WT and PepT1−/− mice. Left panel: Taxonomic cladogram obtained from LEfSe analysis of 16 S sequences. Red, WT taxa; green, PepT1−/− taxa. The brightness of each dot is proportional to the size of its effect size. Right panel: LDA scores for the differentially altered taxa. Red, WT taxa; green, PepT1−/− taxa. Only taxa meeting an LDA significance threshold >2.0 are represented.
