Table 1 Baseline characteristics of subjects.
From: Lung microbiota associations with clinical features of COPD in the SPIROMICS cohort
All (n = 181) | Never-smokers (n = 24) | Smokers, no COPD(FEV1/FVC > 0.70) (n = 79) | Mild/Moderate COPD(50%<FEV1 < 80%) (n = 71) | Severe COPD(FEV1 < 50%) (n = 7) | p-valuea | |
|---|---|---|---|---|---|---|
Age (yrs) | 61 | 55 (42, 71) | 57 (41, 75) | 65 (46, 77) | 65 (42, 74) | <0.001 |
Sex (male %) | 52% | 33% | 49% | 63% | 50% | 0.06 |
Caucasian (%) | 69% | 67% | 61% | 70% | 100% | 0.05 |
Current smoker (%) | 34% | N/A | 43% | 38% | 17% | <0.001 |
Pack-yrs | – | 0 | 35 (20, 113) | 45 (23, 270) | 43 (25, 90) | <0.001 |
FEV1/FVC | 0.72 | 0.81 (0.72, 0.91) | 0.77 (0.57, 0.89) | 0.60 (0.34, 0.77) | 0.52 (0.46, 0.67) | <0.001 |
FEV1 (post-BD, L) | 2.6 | 2.9 (1.9, 2.2) | 2.9 (1.4, 4.8) | 2.2 (0.9, 3.9) | 1.7 (1.3, 2.9) | <0.001 |
FEV1 (post-BD, %pred) | 92.9 | 101.9 (72.5, 118.1) | 98.9 (65.7, 133) | 75.5 (41.1, 111.4) | 54.9 (46.6, 86.6) | <0.001 |
FVC (post-BD, L) | 3.7 | 3.4 (2.3, 5.4) | 3.7 (2.4, 6.0) | 3.8 (2.4, 6.9) | 3.4 (2.7, 4.3) | 0.73 |
FVC (post BD, %pred) | 99.6 | 99.6 (71.6, 113.3) | 99.9 (73.7, 129.6) | 100.9 (67.1, 132.8) | 80.6 (73.4, 94.9) | 0.027 |
FEF25-75 (L/sec) | 1.8 | 3.3 (1.6, 5.4) | 2.6 (0.5, 5.2) | 0.9 (0.3, 2.9) | 0.6 (0.4, 1.5) | <0.001 |
Peak expiratory flow rate (L/sec) | 7.2 | 8.8 (4.3, 11.3) | 8.0 (2.8, 13.3) | 6.3 (3.2, 12.4) | 5.0 (4.1, 7.8) | <0.001 |
Bronchodilator response | ||||||
FEV1 (% change) | 7.3 | 5.0 (−6.8, 13.6) | 6.2 (−13.6, 33.5) | 10.6 (−10.6, 34.2) | 5.1 (2.1, 19.0) | <0.001 |
FVC (% change) | 1.8 | −0.6 (−11.9, 5.9) | 0.5 (−17.7, 19.0) | 6.4 (−8.0, 54.2) | 9.9 (4.6, 31.2) | <0.001 |
Six-minute hall walk distance (meters) | 462 | 490 (357, 645) | 464 (114, 626) | 450 (126, 740) | 451 (360, 576) | 0.35# |
CAT score | 8 | 2 (0, 16) | 7 (0, 32) | 10 (1, 35) | 14 (2, 29) | <0.001# |
SGRQ total score | 16 | 4 (3, 35) | 13 (3, 85) | 25 (3, 83) | 32 (18, 67) | <0.001# |
