Table 3 Correlation analyses between the abnormal metabolites and inflammatory cytokines.

From: Interactions between gut microbiota and metabolites modulate cytokine network imbalances in women with unexplained miscarriage

Metabolites

Correlation coefficient (r)

IL-2

IL-17A

IL-17F

TNF-α

IFN-γ

Hyocholic acid

0.27

0.36

0.29

0.26

0.39

Ursocholic acid

0.29

0.35

0.36

0.28

0.35

Chenodeoxycholic acid sulfate

0.20

0.32

0.45*

0.32

0.35

Hyodeoxycholic acid

−0.09

−0.20

−0.05

−0.13

−0.65**

Isolithocholic acid

−0.09

−0.04

−0.11

−0.23

−0.50*

1,4-Methylimidazoleacetic acid

0.13

0.45*

0.41

0.58**

0.59**

Imidazolepropionic acid

0.15

0.47*

0.47*

0.59**

0.53*

Adrenic acid

0.04

0.43

0.42

0.36

0.38

7-Hydroxy-3-oxocholanoic acid

−0.30

−0.62**

−0.35

−0.44

−0.46*

Lucidenic acid J

0.17

0.23

0.15

0.14

0.44

THA

0.21

0.27

0.17

0.16

0.43

Deoxycholic acid 3-glucuronide

0.20

0.06

0.01

0.20

0.40

L-Carnitine

0.17

0.30

−0.06

0.34

0.54*

Acetylcholine

0.07

0.11

0.07

0.35

0.52*

5alpha-androstane-3alpha-ol-17-one sulfate

0.18

0.23

0.28

0.10

0.31

TXB2

−0.12

-0.47*

−0.32

−0.49*

−0.40

Ergothioneine

0.11

−0.02

−0.01

0.08

0.50*

LysoPC(22:1(13Z))

0.20

0.15

0.34

0.28

0.34

sn-3-O-(geranylgeranyl) glycerol 1-phosphate

−0.30

−0.54*

−0.33

−0.39

−0.18

15-Deoxy-d-12,14-PGJ2

−0.23

−0.50*

−0.26

−0.55*

−0.52*

12(S)-HETE

−0.17

−0.02

−0.37

−0.33

−0.20

Cortisone

−0.19

−0.26

−0.22

−0.34

−0.54*

D-Urobilinogen

0.12

0.25

0.16

0.31

0.46*

12-Oxo-20-carboxy-leukotriene B4

0.19

0.39

0.39

0.42

0.26

7a-Hydroxydehydroepiandrosterone

0.16

0.14

0.09

0.26

0.37

16,16-dimethyl-6-keto Prostaglandin E1

−0.28

−0.37

−0.23

−0.42

−0.32

  1. The asterisk represents the statistical significance between metabolites and cytokines. *p < 0.05, **p < 0.01.
  2. IL interleukin, TNF-α tumor necrosis factor-α, IFN-γ interferon-γ.
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