Fig. 6: Antibiofilm effect of CHAPSH3b, phiIPLA-RODI or a combination of both on premature biofilms in an ex vivo model of intact and wounded skin. | npj Biofilms and Microbiomes

Fig. 6: Antibiofilm effect of CHAPSH3b, phiIPLA-RODI or a combination of both on premature biofilms in an ex vivo model of intact and wounded skin.

From: Synergistic action of phage phiIPLA-RODI and lytic protein CHAPSH3b: a combination strategy to target Staphylococcus aureus biofilms

Fig. 6

Antibiofilm effect of CHAPSH3b, phiIPLA-RODI or a combination of both on premature biofilms in an ex vivo model of intact and wounded skin. A porcine ex vivo model of intact skin (a) and skin wound (b) infection (n = 3) infected with 3-h-old biofilms of S. aureus V329 (~105 CFU/g skin) was treated with either CHAPSH3b (8 µM), phiIPLA-RODI (MOI of 588) or a combination of both (8 µM and MOI of 588, respectively). Bars represent the means and standard deviations of three independent experiments. Bars with an asterisk are statistically different (p < 0.05) from the untreated control according to the Student’s t-test using the Holm-Sidak method.

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