Fig. 1: Diversity and taxonomic composition of oral microbiota.
From: Periodontitis associates with species-specific gene expression of the oral microbiota
a α-diversity patterns as measured by observed richness, Pielou’s evenness and Shannon diversity index. b β-diversity as summarized by Aitchison distance and visualized using PCoA ordination. c Top ten species identified in oral site x health status combinations (27 species in total). Color indicates heath status (blue: healthy controls versus red: periodontitis group), and shape reflects oral site. Significant differences were assessed using Kruskal–Wallis and PERMANOVAS tests for α and β-diversity, respectively. Significant FDR-adjusted p values were indicated as follows: *0.05 > p > 0.01 **0.01 > p > 0.001 ***p < 0.001. Boxplots display first quartile, median, and third quartile and whiskers represent 1.5 times the interquartile range from the first and third quartiles. The top 12 species significantly (p < 0.05) correlated among the PCoA 1 and 2 axes were displayed using vegan::envfit() function. Microbial taxonomic profiles are based on MetaPhlAn v3.0.1—default parameters.
