Fig. 2: Structure of the α-domain of Ag43^EDL_933 (α^43_EDL933), Ag43^UTI89 (α^43_UTI89), and Ag43b (α^43b).

a, b Side and top cartoon representations with β-strands in green, purple and blue, respectively. Turns are coloured in salmon and F1–F3 represent the three faces of the three-stranded β-helix. The two loops (loop 1 and loop 2) that protrude from the β-helices are shown in black, while the four β-hairpins appear in light orange. The AC domain of both α^43_EDL933 and α^43_UTI89 are coloured in hot pink. Side view of α^43a (PDB: 4KH3), depicted in grey is shown for comparison¹³. c Stereo view of the 2Fo−Fc electron density maps contoured at 1σ of a cross-section of α^43_EDL933 (residues T⁶⁵-D⁸⁴), α^43_UTI89 (residues L⁹⁰-E¹⁰⁸) and α^43b (residues I⁵²-D⁷⁰) β-helices. d Superimposition of α^43_EDL933, α^43_UTI89 and α^43b on that of α^43a, with α^43a depicted in grey. The AC domain is displayed in hot pink and light pink for α^43_EDL933 and α^43_UTI89 respectively, with the β-hairpin motifs yellow. RMSD values for all superpositions are shown in Supplementary Table S1.