Table 1 Short-term clinical trials (<4 months) using probiotics for bacterial vaginosis (BV) treatment without antibiotics.
From: The right bug in the right place: opportunities for bacterial vaginosis treatment
Studies | Size | Type of study | Duration | Time | Route of administration | Probiotics and cure rate | Probiotics (CFU) | Control (Placebo) | Control (Antibiotics) | Control (Blank) | Control (Other) | Statistics (Control vs. Probiotics) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Reid et al., 200364 | 64 | R, PC | 90 days | 60 days | Oral capsule | L. rhamnosus GR-1 and L. fermentum RC-14 (37%) | >109 | Yes (13%) | p = 0.02 | |||
Hantoushzadeh et al., 201297 | 300 | R, AC | 1 week | Twice a day/week | Oral yogurt | L. bulgaris, Streptococcus thermophilus, L.acidophilus, and Bifidobacterium lactis (80%) | 100 g yogurt | Clindamycin (84%) | p = NS | |||
Vujic et al., 201355 | 544 | R, PC, DB | 12 weeks | 6 weeks | Oral capsule | L. rhamnosus GR-1 and L. reuteri RC-14 (51.1%) | >109 | Yes (20.8%) | p < 0.001 | |||
Hallén et al., 199298 | 57 | R, DB, PC | 40 days | 6 days | Vaginal plug | L. acidophilus (21%) | 108–9 | Yes (0%) | p = NS | |||
Neri et al., 199399 | 84 | R, AC | 8 weeks | 7 days | Vaginal douche | L. acidophilus (88%) | 108 | Yes (5%) | 5% acetic acid (38%) | p < 0.001 p = 0.04 | ||
Parent et al., 1996100 | 32 | R, PC | 4 weeks | 6 days | Vaginal tablet | L. acidophilus (88%) | ≥107 | Yes (22%) | p < 0.05 | |||
Ozmen et al., 199867 | 211 | R, AC | 1 menstrual period | 12 days | Vaginal suppository | L. acidophilus (55.6%) | 107–7 × 108 | Metronidazole (87.7%) | p < 0.001 | |||
Anukam et al., 200656 | 40 | R, OB, AC | 30 days | 5 days | Vaginal capsule | L. rhamnosus GR-1 and L. reuteri RC-14 (88%) | 109 | Metronidazole (55%) | p = NS | |||
Mastromarino et al., 2009101 | 34 | R, DB, PC | 3 weeks | 7 days | Vaginal tablet | L. brevis CD2, L. salivarius FV2, and L. plantarum FV9 (61%) | ≥109 | Yes (19%) | p < 0.05 | |||
Ya et al., 2010102 | 120 | R, DB, PC | 2 months | Two separate 7 days | Vaginal capsule | L. rhamnosus, L. acidophilus, and Streptococcus thermophilus (84.2 %) | 8 × 109 | Yes (55%) | p < 0.001 | |||
Ling et al., 2013103 | 55 | R, AC | 30 days | 10 days | Vaginal smear | L. delbrueckii subsp. lactis DM8909 (96%) | >109 | Metronidazole (70%) | p = 0.013 | |||
Vicariotto et al., 2014104 | 34 | R, PC | 56 days | 28 days | Vaginal tablet | L. fermentum LF15 and L. plantarum LP01 (83.3%) | 4 × 108 | Yes (10%) | p < 0.001 |
