Table 4 Long term clinical trials (≥4 months) using probiotics for BV treatment with antibiotics.
From: The right bug in the right place: opportunities for bacterial vaginosis treatment
Studies | Size | Type of study | Duration | Antibiotics treatment first | Time | Route of administration | Probiotics and cure rate | Probiotics (CFU) | Control (Placebo) | Control (Blank) | Statistics (Control vs. Probiotics) |
|---|---|---|---|---|---|---|---|---|---|---|---|
Hummelen et al., 201059 | 42 | R, DB, PC | 6 months | Oral 400 mg metronidazole twice daily for 10 days | 25 weeks | Oral capsule | L. rhamnosus GR-1 and L. reuteri RC-14 (42%) | 2 × 109 | Capsule (40%) | p = NS | |
Heczko et al., 201565 | 154 | R, DB, PC | 6 months | Oral metronidazole for 7 days | 10 days | Oral capsules | L.gasseri 57 C, L. fermentum 57 A, and L. plantarum 57B (54.8%) | ≥108 | Capsule (53%) | p = 0.087 | |
Russo et al., 201966 | 48 | R, DB, PC | 6 months | Oral 500 mg metronidazole twice a day for 1 week | 10 days per month | Oral capsule | L. acidophilus GLA-14 and L. rhamnosus HN001 (70.83%) | 5 × 109 | Capsule (41.67 %) | p < 0.05 | |
Larsson et al., 2008109 | 100 | R, DB, PC | 6 menstrual periods | Vaginal 2% clindamycin for 7 days | 10 days for three menstrual cycles | Vaginal gelatine capsules | L. gasseri Lba EB01-DSM 14869 and L. rhamnosus Lbp PB01-DSM 14870 (65%) | 108–109 | Capsule (46%) | p = 0.042 | |
Marcone et al., 2008107 | 84 | R, AC | 180 days | Oral Metronidazole 500 mg twice a day for 7 days | Once a week for 2 months | Vaginal tablet | L. rhamnosus (83%) | >4 × 104 | Yes (67%) | p = NS | |
Marcone et al., 2010110 | 46 | R, AC | 12 months | Oral 500 mg metronidazole for 7 days | 6 months | Vaginal capsule | L. rhamnosus GR-1 and L. reuteri RC-14 (not shown) | >4 × 104 | Yes (not shown) | p = NS | |
Bradshaw et al., 2012111 | 268 | R, DB, PC | 6 months | Vaginal metronidazole for 7 days | 12 days | Vaginal pessary | L. acidophilus KS400 (72%) | ≥109 | Pessary (73%) | p = NS | |
Recine et al., 2016112 | 250 | R, AC | 9 months | Oral 500 mg metronidazole twice a day for 1 week | 7 months | Vaginal tablet | L. rhamnosus BMX 54 (79.7%) | ≥104 | Yes (20.3%) | p < 0.0001 | |
Bohbot et al., 201851 | 78 | R, DB, PC | 196 days | Oral 500 mg metronidazole twice a day for 1 week | 14 days | Vaginal capsule | L. crispatus IP 174178 (79.5%) | 109 | Capsule (59%) | p = 0.049 | |
Cohen et al., 202062 | 228 | R, DB, PC | 24 weeks | Vaginal 0.75% metronidazole for 5 days | 10 weeks | Vaginal applicators | L. crispatus CTV-05 (70%) | 2 × 109 | Inactive ingredient (55%) | p = 0.01 |
