Fig. 4: Host antibody response against periodontal pathogens is significantly abrogated with nisin or nisin-producing probiotic treatment.

Serum IgG antibody levels to P. gingivalis, T. denticola, T. forsythia, and F. nucleatum in all ten groups is shown. Data represent the means ± standard deviation from six mice per group. Statistical significance was determined using Student’s t-test between the two independent groups. The difference in variance with a p-value of <0.05 was considered significant. (a) The difference in serum IgG antibody levels was significant (p < 0.05) compared to the Control group. (b) The difference in serum IgG antibody levels was significant (p < 0.05) compared to the Infection group. *, the difference in serum IgG antibody levels between the two groups was significant (p < 0.05).