Fig. 6: Nisin or nisin-producing probiotic abrogate the host inflammatory cytokine response in gingival tissues. | npj Biofilms and Microbiomes

Fig. 6: Nisin or nisin-producing probiotic abrogate the host inflammatory cytokine response in gingival tissues.

From: Nisin probiotic prevents inflammatory bone loss while promoting reparative proliferation and a healthy microbiome

Fig. 6

To evaluate the immune cytokine profiles in gingival tissues, mRNA expression of IL-1β, IL-6, TNF-α, IFN-γ, CCL2, CXCL2, and TGF-β1 were measured by real-time PCR. The amount of mRNA in each reaction was normalized to GAPDH, which is a housekeeping gene. Data are shown as means ± standard deviation from six mice per group. Statistical significance was determined using Student’s t-test between two independent groups. The difference in variance with a p-value of <0.05 was considered significant. (a) p < 0.05 compared with the Control group. (b) p < 0.05 compared with the Infection group.

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