Fig. 2: Differences in gut microbiota functional gene composition.

a Principal coordinate analysis (PCoA) of individuals in high- and low-altitude populations based on gut microbiota gene-family abundance (Bray–Curtis distance; Adonis test, R2 = 0.15, P < 0.001), The ellipse borders represent the 95% confidence interval. b Heatmap showing the difference in functional enrichment rate of KEGG tertiary pathways of gut microbiota between high-altitude and low-altitude populations of RMs (LEfSe analysis, LDA > 2, P < 0.05).