Fig. 3: Main metabolic modules associated with the differential functional genes (T-test, P < 0.05) of the gut microbiota in high-altitude populations and low-altitude populations of wild RMs.

a Heatmap of major differential genes (log10 relative abundance). b Schematic diagram of main modules involved in differential genes. Red indicates that relative abundance was significantly higher in high-altitude populations. Green indicates that abundance was significantly higher in low-altitude populations. The boxes represent 25th–75th percentiles, black lines indicate the median and whiskers extend to the maximum and minimum values within 1.5× the interquartile range, point represents the actual value of the sample.