Table 1 Agr mutation rates during infection under 3-day low-dose antibiotic treatment.

From: Antibiotic treatment can exacerbate biofilm-associated infection by promoting quorum cheater development

Mutation rate (agr mutant clones/total)

Skin abscess

Catheter infection

PJI

Without antibiotic

0 (0/920)

5.88 × 10−3 (5/850)

0 (0/914)

Levofloxacin

0 (0/908)

1.75 × 10−2 (15/855; p = 0.040a)

5.5 × 10−3 (5/903; p = 0.030a)

Vancomycin

0 (0/916)

1.74 × 10−2 (16/918; p = 0.028a)

5.6 × 10−3 (5/895; p = 0.030a)

  1. aStatistical analysis is by two-tailed Fisher’s exact test versus data obtained without antibiotics in the same infection type.
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