Table 3 Non-synonymous mutations in non-hemolytic clones that developed in the mouse PJI model.
Treatment | Sample no. | Mouse no. | Mutated gene | Mutated location in gene | Amino acid exchange |
|---|---|---|---|---|---|
3d none | No non-hemolytic clones observed | ||||
3d Lev | 1 | 2 | agrC | C541T | Gln181Stop |
2 | 2 | agrA | G683A | Cys228Tyr | |
3 | 2 | agrC | C640T | Gln214Stop | |
4 | 2 | agrC | A1252G | Asn418Asp | |
5 | 3 | agrC | G1024A | Glu342Lys | |
3d Van | 1 | 1 | agrA | C136T | Gln46Stop |
2 | 2 | agrC | G940A | Glu314Lys | |
3 | 2 | agrC | G940A | Glu314Lys | |
4 | 2 | agrC | G940A | Glu314Lys | |
5 | 3 | agrC | A898G | Lys300Glu | |
