Fig. 3: Annotation enrichment of the protein profile of B. longum extracellular vesicles.

a KEGG pathways enriched in B. longum EVs. b Enriched domain and protein families’ categories of the INTERPRO database (P-value and protein count) as analyzed by the DAVID Bioinformatics Resources (LHRI/ADRD at Frederick National Laboratory). The enrichment was done against the bacterial genome background. c STRING analysis and interactions map of the ABC transporters cluster as annotated by KEGG pathway database (purple—ABC transporters, blue—quorum sensing, gray—ATP binding). d STRING analysis and interactions map of the quorum sensing proteins as annotated by KEGG pathway database (blue—quorum sensing, yellow—fatty acid biosynthesis, brown—protein export, purple—ABC transporters, light blue—intrinsic component of membrane).