Fig. 4: Metaproteome landscape of both human and microbiota protein groups in saliva samples.

a Distribution of quantified human and microbial protein groups. Venn diagram indicates the numbers of quantified protein groups, while the bar graph shows the total intensity of human or microbial proteins. b tSNE plot of bacterial protein groups quantified in saliva samples (PERMANOVA, R2 = 0.20, adj.p = 0.089). c tSNE plot of human protein groups quantified in saliva samples (PERMANOVA, R2 = 0.21, adj.p = 0.106). d t-Distributed Stochastic Neighbor Embedding (t-SNE) plot of all proteins quantified in saliva samples (PERMANOVA, R2 = 0.026, adj.p = 0.025). Beta diversity comparisons were performed using Aitchison distance. The ellipses represent a 95% confidence level. Color is indicative of the study group.