Fig. 5: The combined treatment of FMD and anti-PD-1 synergistically retarded tumor growth in subcutaneous tumor model.
From: Fasting-mimicking diet remodels gut microbiota and suppresses colorectal cancer progression
a Schematic diagram of anti-PD-1 treatment of mice. MC38 cells were injected subcutaneously in the same day as FMD started. Mice in control and FMD groups were treated with IgG isotype, mice in anti-PD-1 and FMD+ anti-PD-1 groups were treated with monoclonal antibody at day 9, 12 and 15. Mice were euthanized at day 17. b Average body weight change during the study timeframe. c Image of dissected tumors. d Tumor weight on day of sacrifice. One-way ANOVA. e Average tumor volume measured after MC38 cells injection. Control: n = 6; FMD n = 7; anti-PD-1: n = 7; FMD+anti-PD-1: n = 7. Data are shown in mean ± SD. One-way ANOVA test. *p < 0.05, **p < 0.01, ***p < 0.001.
