Fig. 3: Heatmap showing correlation trends between KO functions according to Spearman’s rho values.

The 50 KO functions with the highest relative abundance among those detected in all datasets and in at least 75% of subjects on average are shown (ribosomal proteins were not included). KO functions are ordered based on hierarchical clustering. Diameter and color of each circle (see legend on the right for color gradient) depend on the weighted average rho value computed via REML meta-analysis for that KO-KO correlation in the 10 datasets. Asterisks mark statistically significant correlations (*** = FDR < 0.001; ** = FDR < 0.01; * = FDR < 0.05). K21572, starch-binding outer membrane protein, SusD/RagB family; K21573, TonB-dependent starch-binding outer membrane protein SusC; K00024, malate dehydrogenase; K00239, succinate dehydrogenase flavoprotein subunit; K04077, chaperonin GroEL; K04043, molecular chaperone DnaK; K13993, HSP20 family protein; K04078, chaperonin GroES; K20276, large repetitive protein; K15125, filamentous hemagglutinin; K00134, glyceraldehyde 3-phosphate dehydrogenase (phosphorylating); K01805, xylose isomerase; K01610, phosphoenolpyruvate carboxykinase (ATP); K03545, trigger factor; K02357, elongation factor Ts; K00874, 2-dehydro-3-deoxygluconokinase; K02358, elongation factor Tu; K03527, 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase; K00927, phosphoglycerate kinase; K02355, elongation factor G; K01624, fructose-bisphosphate aldolase, class II; K01803, triosephosphate isomerase (TIM); K01006, pyruvate, orthophosphate dikinase; K10117, raffinose/stachyose/melibiose transport system substrate-binding protein; K15770, arabinogalactan oligomer / maltooligosaccharide transport system substrate-binding protein; K02035, peptide/nickel transport system substrate-binding protein; K02406, flagellin; K10540, methyl-galactoside transport system substrate-binding protein; K17318, putative aldouronate transport system substrate-binding protein; K10200, N-acetylglucosamine transport system substrate-binding protein; K02027, multiple sugar transport system substrate-binding protein; K10192, oligogalacturonide transport system substrate-binding protein; K01689, enolase; K01179, endoglucanase; K00261, glutamate dehydrogenase (NAD(P) + ); K00262, glutamate dehydrogenase (NADP + ); K03737, pyruvate-ferredoxin/flavodoxin oxidoreductase; K03521, electron transfer flavoprotein beta subunit; K03522, electron transfer flavoprotein alpha subunit; K22432, caffeyl-CoA reductase-Etf complex subunit CarE; K01938, formate--tetrahydrofolate ligase; K01818, L-fucose/D-arabinose isomerase; K00656, formate C-acetyltransferase; K10112, multiple sugar transport system ATP-binding protein; K00248, butyryl-CoA dehydrogenase; K00053, ketol-acid reductoisomerase; K00616, transaldolase; K00260, glutamate dehydrogenase; K00626, acetyl-CoA C-acetyltransferase; K00074, 3-hydroxybutyryl-CoA dehydrogenase.