Fig. 3: Fecal metabolic profiling exposes remarkably increased ceramides in CORT-treated and Abx-FMT/C mice. | npj Biofilms and Microbiomes

Fig. 3: Fecal metabolic profiling exposes remarkably increased ceramides in CORT-treated and Abx-FMT/C mice.

From: Gut microbiota dysbiosis-mediated ceramides elevation contributes to corticosterone-induced depression by impairing mitochondrial function

Fig. 3

a PCA score plot for the metabolomics data acquired from Veh-treated mice and CORT-treated mice in positive ion mode. b PCA score plot for the metabolomics data acquired from Abx-FMT/V mice and Abx-FMT/C mice in positive ion mode. c Volcano plots showing the differential metabolites between Veh-treated mice and CORT-treated mice. The upregulated, downregulated, and unchanged metabolites are presented by red, blue, and gray dots, respectively. d Volcano plots showing the differential metabolites between Abx-FMT/V mice and Abx-FMT/C mice. e The Venn diagram showing differential metabolites unique or shared among the groups. Left: the upregulated metabolites; right: downregulated metabolites. f Heatmap showing the 32 differential metabolites among the groups. Red represents upregulated metabolites, and blue represents downregulated metabolites. g–i Relative abundance of 3 types of ceramides among the groups. N = 10 for each group. Unpaired t tests were used to compare the differences between the two groups. *p < 0.05, **p < 0.01, ***p < 0.001.

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