Fig. 5: PPARγ is essential for C. difficile MVs to inhibit the motility of HTR-8/SVneo cells. | npj Biofilms and Microbiomes

Fig. 5: PPARγ is essential for C. difficile MVs to inhibit the motility of HTR-8/SVneo cells.

From: Clostridium difficile-derived membrane vesicles promote fetal growth restriction via inhibiting trophoblast motility through PPARγ/RXRα/ANGPTL4 axis

Fig. 5: PPARγ is essential for C. difficile MVs to inhibit the motility of HTR-8/SVneo cells.The alternative text for this image may have been generated using AI.

A The inhibitory effect of C. difficile MVs on HTR-8/SVneo cell adhesion was mitigated by T0070907 and PPARγ shRNA. B Down-regulation of FN and VTN by C. difficile MVs was eliminated by T0070907 and PPARγ shRNA in HTR-8/SVneo cells. C, D The inhibition of C. difficile MVs on the migration and invasion of HTR-8/SVneo cells was alleviated by T0070907 and PPARγ shRNA. Data are represented as mean ± SD including at least three replicates. Data was analyzed using ANOVA with Tukey’s post hoc test. *P < 0.05; **P < 0.01; ***P < 0.001.

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